Blood Orange Mezcal Negroni

A complex and delicious sipper, Blood Orange Mezcal Negroni might rock your world.😉Mezcal, Campari, blood orange cordial, and fresh lime juice shaken with ice and strained into a smoked salt rimmed rocks glass!

A close up of a blood orange mezcal negroni in a rocks glass with a slice of blood orange.

👩🏻‍🍳 Tamara Talks – Cocktail Inspiration

Don’t let the gorgeous hue of this mezcal cocktail fool you! This is not a cocktail for lightweights, nor is it simple, straightforward, or sweet. I love alliteration. 🙂

Prior to moving to McAllen, Texas in 2015, tequila didn’t really interest me, and I’d never even heard of mezcal. I’m a martini girl (since before I was legal), and I love good gin. Case in point: Ginger Hibiscus Martini, Orange Vesper Martini, Lemon Cucumber Martini with Fresh Basil, and Apple and Sage Martini. These are my recipes on my blog. Lol.

Tequila is a way of life in south Texas – especially given that we are only a few miles from Mexico… I started playing with tequila, and I brought you An Exotic Tropical Margarita, a Savory Margarita, and most recently, a Tequila Cocktail with Blood Orange and Pomegranate.

Given my propensity for complex flavors, it was only a matter of time before I introduced myself to mezcal. Wow. The smokiness of this agave-based spirit speaks to me! If you’re interested in learning more about this complex spirit, check out Beyond Tequila: Alternative Agave Spirits to Know!

We (hubby Mark and I) had a couple of epic fails in the process of figuring out how to mix a mezcal cocktail. We won’t discuss those today… However, this combination just works. It is so well-balanced! If you love mezcal, you won’t want to miss this tamarind mezcal cocktail

A Blood Orange Mezcal Negroni with a cutting board, knife, blood orange, and lime.

🍹 Cocktail Ingredients


  • Made from a variety of agaves (unlike tequila which is made from Blue Weber agave)
  • Majority of mezcal is made in Oaxaca, Mexico
  • Colors range from clear to light gold to amber
  • Agave hearts are charred, and roasted in deep pits called “palenques”
  • The smokiness the charring imparts may remind you of Scotch, but it is unique


  • Campari is considered an “apéritif”
  • It is an infusion of bitter herbs, aromatics, and fruit in alcohol and water
  • Its color is brilliant red (much like blood orange)
  • While bitterness is a major flavor, it is a little sweet, fruity, and citrus-y as well
  • Campari is an iconic before meal sipper
  • The Negroni is a classic cocktail that includes gin and Campari (and I adore them!)

Blood Orange Cordial

  • Blood orange cordial is basically a simple syrup with blood orange – both juice and zest
  • The cordial is great in both cocktails and non-alcoholic beverages
  • You can make your own, or purchase it ready-made

To Finish

  • Fresh Lime Juice (do you need this explained?)
  • Smoked Sea Salt (optional)

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If you’ve chosen to make the blood orange cordial, make it first, and allow it to cool completely. Squeeze the lime juice. Add ice to your shaker.

If choosing to rim your glasses with smoked sea salt, do that now. Add ice to your rocks glasses. We love using a single cube. but that is totally optional.

  1. Add mezcal, Campari, blood orange cordial, and fresh lime juice to a shaker filled with ice.
  2. Shake vigorously.
  3. Strain into rocks glasses with ice.
  4. Garnish as desired

🎥 Video

💭 Tips

If you don’t wish to make your own blood orange cordial, you can find blood orange cordial here.

What makes this mezcal cocktail a “negroni?”

A negroni is a classic cocktail that includes gin and Campari. This mezcal would be considered by some (including me) to be a negroni variant, and I included it in the title to help people find it that love Campari.

Playing with cocktails isn’t “healthy” in a strict sense, but it “sparks joy” (quoting Marie Kondo), so I submit it can be healthy… All things in moderation! If you love mezcal, and want more mezcal cocktail recipes, be sure to check out this tamarind mezcal mule.

Signature in red and green with chiles and limes.
P.S. Click here for a “how to” video on making Blood Orange Cordial!

2 Blood Orange Mezcal Negronis in rocks glasses with a slice of blood orange.

Blood Orange Mezcal Negroni

Mezcal, Campari, blood orange cordial, and fresh lime juice shaken with ice and strained into a smoked salt rimmed rocks glass!
4.85 from 19 votes

Click to rate!

Prep Time 5 minutes
Additional Time to Make Cordial 30 minutes
Total Time 35 minutes
Course Beverages
Cuisine American
Servings 2 cocktails
Calories 326 kcal



  • 4 ounces mezcal - see notes
  • 2 ounces Campari
  • 2 ounces blood orange cordial - purchased or recipe below
  • 1 ounce fresh lime juice

Blood Orange Cordial



  • Add mezcal, Campari, blood orange cordial, and fresh lime juice to a shaker filled with ice.
  • Shake vigorously.
  • Strain into rocks glasses with ice.
  • Garnish as desired


You need to allow about 30 minutes if you’re making the blood orange cordial. You can buy it on Amazon if you prefer.
I keep an array of artisan salts in my well-stocked pantry, and that includes apple wood smoked salt.
I have a “how to” video on making a Blood Orange Cordial, or you can buy a commercial one (see “Recommended Products” below).


Calories: 326kcal

NOTE: Macronutrients are an approximation only using unbranded ingredients and Please do your own research with the products you’re using if you have a serious health issue or are following a specific diet.

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